Dulaglutide (Trulicity)
Dulaglutide (LY2189265), a recombinant GLP-1 receptor agonist fused to a modified human IgG4 Fc fragment (PMID 25912221; FDA label 2025).
Approved status applies to specific products, routes, and indications, not every use context discussed online.
An FDA-approved once-weekly injection (Trulicity) for type 2 diabetes that controls blood sugar and also reduces the risk of heart attack and stroke in people with heart disease or multiple risk factors. Also approved for children age 10 and older with type 2 diabetes.
Dulaglutide (Trulicity) is FDA-approved.
Use according to current labeled indication and prescribing guidance.
Safety Summary
In a pooled analysis of 787 Chinese patients from AWARD-CHN1/CHN2, 28.6% reported at least one GI treatment-emergent adverse event (TEAE) by week 26. The most frequent were diarrhea (13.1%), nausea (6.6%), abdominal distension (6.4%), and vomiting (3.0%). Per FDA label, GI events were graded mild in approximately 48-58%, moderate in 35-42%, and severe in 7-11% of cases, with events peaking during the first 2 weeks and declining thereafter (PMID 32621083; FDA label 2025). Pancreatic amylase increased modestly within normal range (LS mean +5.7 U/L at 26 weeks) without associated pancreatitis events PMID 34453682.
Clinical check-in
If real-world use or exposure is being considered, review potential interactions, contraindications, and monitoring needs with a licensed clinician rather than relying on summary copy alone.
Cited sources
Every claim on this page links to one of the 21 sources below. Identifiers are PubMed (PMID), ClinicalTrials.gov (NCT), or DOI; click through to the source of record before acting on a claim.
- 1PMID 24742660PubMed
- 2PMID 25912221PubMed
- 3PMID 31183384PubMed
- 4PMID 33591618PubMed
- 5PMID 33239067PubMed
- 6PMID 33537745PubMed
- 7PMID 36894938PubMed
- 8PMID 34453682PubMed
- 9PMID 32621083PubMed
- 10PMID 32219675PubMed
- 11PMID 31228090PubMed
- 12PMID 30949907PubMed
- 13PMID 31758520PubMed
- 14PMID 31994009PubMed
- 15PMID 29430801PubMed
- 16PMID 28606095PubMed
- 17PMID 27161178PubMed
- 18PMID 33460016PubMed
- 19PMID 39768420PubMed
- 20PMID 40214296PubMed
- 21PMID 32857293PubMed