Pinealon

Safety Profile

How It Works

Pinealon is a tiny three-amino-acid peptide that works as a brain protector. It can enter brain cells and their nuclei, where it appears to turn on genes that produce antioxidant enzymes (the brain's natural defense against oxidative damage). It also dials down the signals that tell brain cells to self-destruct (apoptosis). Think of it like a maintenance crew that helps keep neurons healthy under stress -- it does not stimulate the brain like caffeine, but rather supports the cells' own repair and defense systems. In lab and animal studies, it helped neurons survive oxygen deprivation and toxic stress, and in Alzheimer's disease models it prevented the loss of dendritic spines (the tiny connection points between neurons essential for memory). However, the exact gene targets and real-world human relevance are still not firmly established.

Reported Dosing References

Used in locomotive brigade workers in a Russian occupational-health study; this is a descriptive clinical-use regimen, not a dose-finding trial (PMID 22708445).

Studies

Pinealon (Glu-Asp-Arg) is a synthetic tripeptide studied primarily by a single Russian research group (Khavinson et al.) with no independent replication and no randomized controlled trials.

Legal Status

Not identified as an FDA-approved drug. Raw FDA searches found no Drugs@FDA match, no label match, and no FAERS match, and raw ClinicalTrials.gov exports found zero registered Pinealon studies as of 2026-03-09. Not a controlled or scheduled substance. Available as a research chemical or dietary supplement from peptide vendors. No FDA enforcement actions identified in source data.